I started a testosterone blocker (spironalactone) and estradiol on Wednesday. As expected, it didn't have much of an effect the first couple of days. Steroids generally take months to have an effect, although the blocker is faster. Oddly, at least to me, I woke up on the third day feeling very at peace in my body. It was like a background noise that you become so used to it escapes your attention until it is turned off. I woke up with a sense of presence in my body, in my muscles, that I don't remember ever having experienced in my life. My initial reaction is that it must be in my imagination, but it was a noticeable sensation.