Softer skin? Probably just in my imagination. While the physical changes of the estradiol will take time, there have already been psychological changes that make me wonder how quickly changes in plasma steroid levels can affect neurochemistry. Certainly the blockers are having an affect, and the low level energy I now associate with testosterone is continuing to drop. It's an odd feeling to have that physical background noise continue to fade, and it still makes me sit in my body in a much more comfortable way.